Ozzy is ordered to assist Drix's investigation while Thrax takes over a gang of sweat germs run by local crime boss Scabies and attacks the dam in Frank's nose, nearly killing Drix before Ozzy saves him. To placate his secretary Leah Estrogen, Phlegmming instructs Frank to take a cold pill, Special Agent Drixenol 'Drix' Drixobenzometaphedramine, who disinfects the throat but unknowingly covers up evidence of Thrax's arrival. This induces Frank to eat a boiled egg that fell into a chimpanzee's habitat, allowing Thrax, a virus known as 'La Muerte Roja' ('The Red Death'), to enter his body. Inside his body, called the 'City of Frank' by its anthropomorphic inhabitants, white blood cell Osmosis 'Ozzy' Jones is a quick-witted officer of the Frank Police Department whose attempts to catch germs end up causing trouble in Frank's body.ĭesperate to be re-elected, the corrupt Mayor Phlegmming doubles down on his junk food policies, ignoring their effect on Frank's health. He copes with the death of his wife named Maggie DeTorre by overeating and foregoing basic hygiene, much to his daughter Shane's embarrassment. Despite the poor financial response, the film was followed by the animated television series Ozzy & Drix, which aired on Kids' WB from 2002 to 2004.įrank DeTorre is an unhealthy, sick, ill zookeeper at Sucat Memorial Zoo in Rhode Island. The film was also a commercial failure, grossing $14 million worldwide against a $70 million budget. It received mixed reviews from critics, who praised the world building, the animation, story, and voice performances, but criticized the inconsistent tone of the live-action portions and overuse of gross-out humor. The film premiered on August 7, 2001, and was released theatrically three days later. It follows the title character, an anthropomorphic white blood cell, as he teams up with a cold pill to protect his unhealthy human host from a villainous virus.

Combining live-action sequences directed by the Farrelly brothers and animation directed by Piet Kroon and Tom Sito, the film stars the voices of Chris Rock, Laurence Fishburne, David Hyde Pierce, Brandy Norwood, and William Shatner alongside Molly Shannon, Chris Elliott, and Bill Murray in live-action roles. Osmosis Jones is a 2001 American live-action/animated action comedy film written by Marc Hyman.

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